A Computational Model of Red Blood Cell Dynamics in Patients with Chronic Kidney Disease
نویسندگان
چکیده
Kidneys are the main site of production of the hormone erythropoietin (EPO) that is the major regulator of erythropoiesis, or red blood cell production. EPO level is normally controlled by a negative feedback mechanism in the kidneys, but patients with chronic kidney disease (CKD) do not produce sufficient levels of EPO to maintain appropriate blood hemoglobin concentration. A mathematical model, including interactions with iron and inflammation, is developed for erythropoiesis in patients with CKD. Numerical solution methodologies and validation of numerical results are discussed. Simulation results under varying conditions and treatment protocols are presented. Further author information: (Send correspondence to Karen M. Bliss.) Karen M. Bliss: [email protected] H. T. Banks: [email protected] Peter Kotanko: [email protected] Hien Tran: [email protected]
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